1-Fluoronaphthalene | CAS: 321-38-0

Fluoronaphthalene Basic Information, Physicochemical Properties, etc.

Basic Information
Name	1-Fluoronaphthalene
Synonyms	1-Fluornaftalen;1-fluoro-naphthalen;NSC 4690;α-fluorinated naphthalene;Duloxetine USP IMpurity G;naphthyl fluoride C10H7F, α;Duloxetine EP IMpurity G;1 – fluorinated naphthalene
CAS Number	321-38-0
Molecular Formula	C10H7F
Molecular Weight	146.16
EINECS Number	206-287-0
Structural Formula
Physicochemical Properties
Melting Point	-13 °C (lit.)
Boiling Point	215 °C (lit.)
Density	1.1322 g/mL at 20 °C (lit.)
Refractive Index	n20/D 1.593(lit.)
Solubility	Slightly soluble in water, freely soluble in chloroform, ethyl acetate and methanol.
Water Solubility	Not miscible or difficult to mix in water.
Form	Oily
Color	Colorless to yellow
Stability	Stable. Incompatible with strong oxidizing agents.
Proportion	1.332
Safety and Regulatory Information
Merck
BRN	1906413
NIST Chemical Substance Information	Naphthalene, 1-fluoro-(321-38-0)
EPA Chemical Substance Information	1-Fluoronaphthalene (321-38-0)
Other Information
Detection Methods

1-Fluoronaphthalene Application, Use, Usage, Synthesis Method, etc.

Application:

1. 1-Fluoronaphthalene as a pharmaceutical intermediate, organic synthesis reagent

1-Fluoronaphthalene is a key intermediate of duloxetine.

Duloxetine is an antidepressant with dual inhibitory effects on the reabsorption of serotonin and norepinephrine. It can treat depression, stress incontinence and pain, and is used to treat diabetes.

2. Used in the production of APIs in the pharmaceutical industry

Fluorinated intermediates have the characteristics of high efficacy and low side effects in pharmaceutical synthesis, and can adjust parameters such as electronics and lipophilicity, making the drug performance superior.

3. 1-Fluoronaphthalene is also used in the petroleum industry and other chemical synthesis fields. Its strong stability and physiological activity make it important in many industrial fields.

1-Fluoronaphthalene Synthesis Method

The main fluorination methods on aromatic rings are:

1. Fluorination is carried out directly with common fluorination reagents or under catalytic conditions.
2. Some special fluorination reagents, such as patents CN14M195A and US4394527, were used.
3. Use fluorine to replace other halogens for fluorination.
4. The method of replacing amino groups by diazotization reaction, such as patent CN1887833.

Detailed introduction of a synthesis method

1. Diazotization reaction:

Add 550g of hydrochloric acid solution (mass concentration is 20%) and 100g of naphthylamine to a 1000 mL three-necked flask, stir and heat to 75℃ to dissolve, cool to below 5℃, and slowly add 50g of sodium nitrite at this temperature. After adding, stir at a low temperature for 0.2 hours to obtain a diazonium salt solution.

2. Substitution reaction:

Add 150g of fluoroboric acid solution (mass concentration is 40%) to the generated solution obtained in step 1, stir for 0.25h, filter, and dry the filter cake at 65℃ for 0.2h to obtain dry naphthylamine diazonium fluoroboric acid complex salt.

3. Hot air decomposition:

The dried diazonium salt fluoroborate complex salt is slowly added into a reactor with hot air (hot air temperature is 85-90℃), and the dried powdered naphthylamine diazonium salt fluoroborate complex salt is blown up and dispersed by the hot air and absorbs heat for thermal decomposition to obtain a 1-fluoronaphthalene solution containing a small amount of solid impurities.

4. Purification treatment:

The 1-fluoronaphthalene solution obtained in step 3) is first washed with pure water for 3-6 times, then neutralized with soda ash to a pH of 6.8-7.2, and finally filtered to separate the oil layer, and the filtrate is distilled to obtain 69g of naphthalene-based fluorinated intermediate 1-fluoronaphthalene with a content of 99.6%.

1-Fluoronaphthalene Packaging, Storage, Delivery, Transportation, etc.

Packing: 25kg /drum or Customer specified packaging

Storage: Stored in a cool, dry, and ventilated warehouse. Packing Sound.

Delivery: delivery within 3- 5 working days

Transportation: According to your needs

FAQ About 1-Fluoronaphthalene

What is the shelf life of Naphthalene, 1-fluoro-?

Answer:

It can be stored for 2-3 years when sealed and protected from light. It is recommended to be used within 1 year after opening.

Where can I buy Fluoronaphthalene? Price and minimum order quantity?

Answer:

Purchase through chemical suppliers (such as Sigma-Aldrich, TCI, ORIENTRED).

The minimum order quantity for laboratory grade starts at 1 gram, and the industrial grade requires more than 100 grams.

You can contact us to get the latest product prices.

Is Fluoronaphthalene toxic?

Answer:

1-Fluoronaphthalene has a slow biodegradation rate in soil and may accumulate in the soil, causing potential harm to the ecosystem.

There are relatively few studies on the ecotoxicity of 1-fluoronaphthalene, but some studies have shown that it may cause certain toxic effects on aquatic organisms and terrestrial plants.

1-Fluoronaphthalene may pose certain health risks to humans. For example, 1-fluoronaphthalene may cause damage to the human liver and kidneys, and may also affect the human immune and nervous systems.