1-Bromo-4-chlorobutane | CAS: 6940-78-9

 1-Bromo-4-chlorobutane Basic Information, Physicochemical Properties, etc.

Basic Information
Name	1-Bromo-4-chlorobutane
Synonyms	1-BroMo-4-chlorobutane,99%25GR;4-BromobutylChloride4-ChlorobutylBromide;1-broMine-4-chlorobutane;1-BroMo-4-chlorobutane,97+%;1-Bromo-4-chL;BrexpiprazoleImpurity66;1-BROMO-4-CHLOROBUTANE,98%1-BROMO-4-CHLOROBUTANE,98%1-BROMO-4-CHLOROBUTANE,98%1-BROMO-4-CHLOROBUTANE,98%;BUTANE,1-BROMO-4-CHLORO-
CAS Number	6940-78-9
Molecular Formula	C4H8BrCl
Molecular Weight	171.46
EINECS Number	230-089-3
Structural Formula
Physicochemical Properties
Melting Point	96-97 °C(Solv: hexane (110-54-3); ethyl acetate (141-78-6))
Boiling Point	80-82 °C/30 mmHg (lit.)
Density	1.488 g/mL at 25 °C (lit.)
Refractive Index	n20/D 1.4875(lit.)
Solubility	Soluble in chloroform
Water Solubility	SLIGHTLY SOLUBLE
Form	Liquid
Color	Colorless to pale yellow
Flash Point	140 °F
Acidity Coefficient (pKa)
Safety and Regulatory Information
Merck
BRN	1098275
NIST Chemical Substance Information	1-Bromo-4-chlorobutane | CAS: 6940-78-9
EPA Chemical Substance Information	1-Bromo-4-chlorobutane | CAS: 6940-78-9
Other Information
Detection Methods

 1-Bromo-4-chlorobutane Application, Use, Usage, Synthesis Method, etc.

It is mainly used in medicine, spices, pesticides, dyes, and other organic synthesis intermediates.

1-Bromo-4-chlorobutane is a halogenated alkane compound containing bromine and chlorine atoms, which can react with ketone compounds (such as quinoline-2,4 (1H, 3H)-dione) to prepare other organic heterocyclic compounds.

For example

Pharmaceutical field

1-Bromo-4-chlorobutane is an important raw material for drug synthesis, such as the synthesis of broad-spectrum antibiotic cilastatin sodium.
In addition, 1-Bromo-4-chlorobutane can also be used to synthesize the antiarrhythmic drug azithromycin hydrochloride.

Material field

At room temperature, 1-Bromo-4-chlorobutane is grafted onto the main chain of polybenzimidazole by substitution reaction to obtain chlorobutyl functionalized polybenzimidazole.

Organic synthesis

Used in the synthesis of p-phenylbutoxybenzoic acid.

Chlorobenzene reacts with magnesium to obtain a Grignard reagent, which is then coupled with 1-bromo-4-chlorobutane to obtain 1-chloro-4-phenylbutane, which is then condensed with p-hydroxybenzoic acid to obtain p-phenylbutoxybenzoic acid.

Synthesis method

1. Prepare butane, bromine liquid and chlorine gas as raw materials. Butane can be obtained through the petroleum refining process, and bromine liquid and chlorine gas are prepared by chemical methods.
2. To improve the reaction efficiency and product purity, the raw materials need to be treated. The bromine liquid and chlorine gas are dried to remove the moisture therein. At the same time, butane is dehydrated to avoid the influence of moisture during the reaction.
3. The pretreated raw materials are reacted. During the reaction, the bromine liquid and chlorine gas are first mixed and then passed through the reactor. In the reactor, the mixed gas and butane undergo a substitution reaction to generate 1-bromo-4-chlorobutane. The temperature, pressure and reaction time need to be controlled during the reaction. To ensure the smooth progress of the reaction and the purity of the product.
4. After the reaction is completed, the product is separated from the reaction system. First, the reaction solution is washed with water to remove acidic gases and impurities. Then butane is separated by distillation to obtain purer 1-bromo-4-chlorobutane.
5. In order to further improve the purity of the product, the separated 1-bromo-4-chlorobutane can be refined. Impurities and by-products are removed by molecular distillation and other methods.

 1-Bromo-4-chlorobutane Packaging, Storage, Delivery, Transportation, etc.

Packing: 180kg /drum or Customer specified packaging

Storage: Store in a cool place. Keep container tightly closed in a dry and well-ventilated place.

Delivery: delivery within 3- 5 working days

Transportation: According to your needs

FAQ About  1-Bromo-4-chlorobutane

Where can I buy 1-bromo-4-chlorobutane? Price and minimum order quantity?

Answer:

Purchase through chemical suppliers such as Sigma-Aldrich, TCI, ORIENTRED.

You can contact us at any time to get the latest quote for 1-bromo-4-chlorobutane.

The minimum order quantity for laboratory grade is usually 10 grams.

What are the advantages of 1-bromo-4-chlorobutane?

Answer:

Its structure is relatively simple and easy to synthesize and handle, so it is often used as an intermediate in organic synthesis.

Through further chemical transformations, such as nucleophilic substitution reactions, elimination reactions, etc., this substance can be used to synthesize more complex organic compounds. These compounds may have specific chemical properties and applications, such as drug synthesis, polymer synthesis, etc.

1-bromo-4-chlorobutane contains two different halogen atoms, namely bromine and chlorine. This structural feature makes it possible to use the different properties of halogens in organic synthesis to achieve selective regulation of reactions.

By choosing appropriate reaction conditions and reagents, selective substitution or elimination of bromine or chlorine can be achieved, thereby controlling the reaction path and product generation.

What is its shelf life?

Answer:

It can be stored for 1-2 years if sealed and protected from light. It is recommended to be used within 6 months after opening.