1-Bromo-3,5-dimethoxybenzene Basic Information, Physicochemical Properties, etc.
| Basic Information |
| Name |
1-Bromo-3,5-dimethoxybenzene |
| Synonyms |
1-BROMO-35-DIMETHOXYBENZENE97;1-Bromo-3,5-dimethox;1-Bromo-3,5-dimethoxybenzene,97%solid;3-Dimethoxybromobenzene;Chemicalbook3，5-Dimethoxybromobenzene;1-Bromo-3,5-dimethoxybenzene;1-BroMo-3,5-diMethoxybenzene97%;1-Bromo-3,5-dimethoxybezene |
| CAS Number |
20469-65-2 |
| Molecular Formula |
C8H9BrO2 |
| Molecular Weight |
217.06 |
| EINECS Number |
695-168-0 |
| Structural Formula |
 |
| Physicochemical Properties |
| Melting Point |
62-66 °C (lit.) |
| Boiling Point |
246.0±20.0 °C(Predicted) |
| Density |
1.412±0.06 g/cm3(Predicted) |
| Refractive Index |
|
| Solubility |
Soluble in methanol. |
| Water Solubility |
|
| Form |
Crystals or crystalline powder |
| Color |
White to yellow |
| Stability |
|
| Acidity Coefficient (pKa) |
|
| Safety and Regulatory Information |
| Merck |
|
| BRN |
|
| NIST Chemical Substance Information |
|
| EPA Chemical Substance Information |
|
| Other Information |
| Detection Methods |
|
1-Bromo-3,5-dimethoxybenzene Application, Use, Usage, Synthesis Method, etc.
The main uses include as an intermediate for biochemical reagents and drug inhibitors, and in life science-related research. Specifically, it can be used to synthesize drug inhibitors through cross-coupling reactions.
In addition, 1-bromo-3,5-dimethoxybenzene can also be used to synthesize organic compounds such as aromatic carboxylic acid compounds and asymmetric squaryl cyanine small molecules.
For example
Synthesis of aromatic carboxylic acid compounds: Through specific chemical reaction steps, 1-bromo-3,5-dimethoxybenzene can participate in the synthesis of aromatic carboxylic acid compounds with a yield of 65%.
Synthesis of N-(6-(3,5-dimethoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-4-((3R,5S)-3,5-dimethylpiperazin-1-yl)benzamide: In this process, 1-bromo-3,5-dimethoxybenzene is used as a key intermediate with a yield of 93.2%.
Preparation of asymmetric phthalocyanine small molecules: In the process of synthesizing asymmetric phthalocyanine small molecules, 1-bromo-3,5-dimethoxybenzene is also an important intermediate.
Synthesis Method
At 0°C, a small amount of 7.4 g (107 mmol) of sodium nitrate in 15 mL of distilled water was added to a solution of 10.0 g (65.3 mmol) of 3,5-dimethoxyaniline in 30 mL of 48% hydrobromic acid until the presence of the diazonium salt was observed with starch potassium iodide paper.
Meanwhile, a mixture of 5.2 g (36 mmol) of cuprous bromide in 5.2 mL of 48% hydrobromic acid was heated to a boil in another flask.
The prepared diazonium salt solution was added in small amounts to the cuprous bromide-hydrobromic acid solution, maintaining its boiling point.
After the addition was complete, the total reaction mixture was stirred and heated for another 30 minutes, and the resulting crude product was purified by steam distillation, collecting 7.84 g of 1-bromo-3,5-dimethoxybenzene as a white solid with a yield of 55.8% and a melting point of 63-64°C.
1-Bromo-3,5-dimethoxybenzene Packaging, Storage, Delivery, Transportation, etc.
Packing: 25kg /drum or Customer specified packaging
Storage: Sealed, cool, dry place
Delivery: delivery within 3- 5 working days
Transportation: According to your needs
FAQ About 1-Bromo-3,5-dimethoxybenzene
Where can I buy 1-Bromo-3,5-dimethoxybenzene? Price and minimum order quantity?
Answer:
Purchase through chemical suppliers (such as Sigma-Aldrich, TCI, ORIENTRED) or pharmaceutical intermediate companies.
Please feel free to contact us for the latest quote.
The minimum order quantity usually starts at 1 gram (laboratory grade).
Are special conditions required for transportation?
Answer:
Sealed transportation at room temperature, no dangerous goods certificate is required, but light-proof and moisture-proof packaging is required.
How to deal with waste?
Answer:
Submit the remaining and unrecovered solution to the disposal company.
Contaminated packaging is discarded as unused product.
