(R)-(+)-2-Chloropropionic Acid Basic Information, Physicochemical Properties, etc.
| Basic Information |
| Name |
(R)-(+)-2-Chloropropionic Acid |
| Synonyms |
D-2-CHLOROPROPIONIC ACID; D-(A)-CHLOROPROPIONIC ACID; D-ALPHA-CHLOROPROPIONIC ACID; (R)-(+)-2-CHLOROPROPANOIC ACID ; (R)-(-)-2-CHLOROPROPIONIC ACID; (R)-(+)-2-CHLOROPROPIONIC ACID; R-2-CHLOROPROPIONIC ACID; (R)-(+)-2-CHLOROPROPIONOIC ACID; (2R)-2-Chloropropionic Acid; D-Chloropropionic Aci; Propanoic acid, 2-chloro-, (2R)-; D-Chloropropionic Acid |
| CAS Number |
7474-05-7 |
| Molecular Formula |
C3H5ClO2 |
| Molecular Weight |
108.52 |
| EINECS Number |
626-432-5 |
| Structural Formula |
 |
| Physicochemical Properties |
| Melting Point |
-12°C |
| Boiling Point |
185-188 °C (lit.) |
| Density |
1.258 g/mL at 20 °C (lit.) |
| Refractive Index |
n20/D 1.4345(lit.) |
| Solubility |
Soluble in chloroform, methanol |
| Flash Point |
140 °F |
| Form |
Transparent liquid |
| Color |
Colorless to light yellow |
| Specific Rotation |
14 º (neat)
|
| Acidity Coefficient (pKa) |
2.96±0.10(Predicted) |
| Safety and Regulatory Information |
| Merck |
/ |
| BRN |
1720258 |
| NIST Chemical Substance Information |
/ |
| EPA Chemical Substance Information |
/ |
| Other Information |
| Detection Methods |
/ |
(R)-(+)-2-Chloropropionic Acid Application, Use, Usage, Synthesis Method, etc.
- An important pharmaceutical intermediate
- The starting material for making the nutritional medicine L-alanyl-L-glutamine
- Synthesis of thiolactic acid
- Synthesis of 2(R),5(S)-oxothioacetone precursor
- Synthesis of (R)-2-chloropropionyl chloride for the preparation of pyrazolopyridine-containing phosphodiesterase inhibitors.
- Starting material for 2-chloropropionamide derivatives used as protein disulfide isomerase (PDI) inhibitors.
- …
Synthesis Method
Method 1: Under the action of acyltransferase, DL-acetylalanine is converted into a-chloropropionic acid by the Fischer method, and L-chloropropionic acid and D-chloropropionic acid are separated by Podbielniak Column distillation.
Method 2: The racemate is split by the lipase of columnar Candida albicans, and the corresponding racemic acid is prepared by enzymatic esterification. One of the enantiomers is esterified and the other remains as an acid. Then, the optically active compounds are separated by distillation or extraction, and D- or L-isomers with a concentration of 70% to 95% can be obtained.
Method 3: Using L-lactic acid as the starting material, R-(+)-2-chloropropionic acid is obtained by esterification, chlorination, and hydrolysis.
(R)-(+)-2-Chloropropionic Acid Packaging, Storage, Delivery, Transportation, etc.
Packing: 230kg/drum or Customer specified packaging
Storage: It should be placed in a cool and dry.
Delivery: Delivery within 3- 5 working days
Transportation: According to your needs
FAQ About (R)-(+)-2-Chloropropionic Acid
What is the purity of pharmaceutical grade (R)-(+)-2-chloropropionic acid?
Answer:
The purity levels of (R)-(+)-2-chloropropionic acid provided by different manufacturers vary.
ORIENTRED provides high purity grades (≥99%) of (R)-(+)-2-chloropropionic acid which are typically used in pharmaceutical applications.
Where can I buy (R)-(+)-2-chloropropionic acid?
Answer:
You can buy (R)-(+)-2-chloropropionic acid at ORIENTERED. We provide high purity pharmaceutical (R)-(+)-2-chloropropionic acid.
Welcome to contact us anytime!
