(1S,2S)-(-)-1,2-Diphenylethylenediamine Basic Information, Physicochemical Properties, etc.
| Basic Information |
| Name |
(1S,2S)-(-)-1,2-Diphenylethylenediamine |
| Synonyms |
(1S,2S)-(-)-1,2-Diphenyl-1,2-ethanediamine,99%,ee:99%;(1S,2S)-(-)-1,2-Diphenylethylenediamine,99%;(1S,2S)-(-)-1,2-Diph;1S,2S-diphenylethane-1,2-diamine;(1S,2S)-(-)Chemicalbook-1,2-Diphenyl-1,2-ethanediamineee;(1S,2S)-(-)-1,2-Diphenyl-1,2-ethanediamine,99%,99%ee;((1S,2S)-2-AMino-1,2-diphenylethyl)aMine;(S,S)-1,2-DiaMino-1,2-diphenylethane |
| CAS Number |
29841-69-8 |
| Molecular Formula |
C14H16N2 |
| Molecular Weight |
212.29 |
| EINECS Number |
608-420-1 |
| Structural Formula |
 |
| Physicochemical Properties |
| Melting Point |
83-85 °C(lit.) |
| Boiling Point |
342.14°C (rough estimate) |
| Density |
1.0799 (rough estimate) |
| Optical Activity |
[α]20/D 102°, c = 1 in ethanol |
| Refractive Index |
-103 ° (C=1, EtOH) |
| Solubility |
DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly) |
| Water Solubility |
Insoluble in water
|
| Form |
Crystal |
| Color |
White to pale yellow |
| Appearance |
Colorless needle-shaped crystals are odorless, insoluble in water, easily soluble in methanol and ethanol, and easily oxidized in the air. |
| Acidity Coefficient (pKa) |
9.78±0.10(Predicted) |
| Safety and Regulatory Information |
| InChIKey |
PONXTPCRRASWKW-KBPBESRZSA-N
|
| BRN |
3201645 |
| NIST Chemical Substance Information |
/ |
| EPA Chemical Substance Information |
/ |
| Other Information |
| Detection Methods |
HPLC |
(1S,2S)-(-)-1,2-Diphenylethylenediamine Application, Use, Usage, Synthesis Method, etc.
1. (1S,2S)-1,2-Diphenylethylenediamine is a compound that can be used in organic synthesis.
2. Widely used in asymmetric synthesis and optical resolution:
- Asymmetric hydroxylation of olefins
- Asymmetric aldol condensation
- Asymmetric Diels-Alder reaction
- Asymmetric allylation of carbonyl
- Synthesis of optically active allenyl alcohols and propargyl alcohols
- Asymmetric epoxidation of olefins without functional groups
- Resolution of binaphthol
- …
Preparation
The current preparation method is to treat (±)-1,2-diphenylethylenediamine in ethanol solvent with tartaric acid as a resolution agent, and adopt different resolution conditions according to the needs to obtain (1S,2S)-1,2-diphenylethylenediamine or (1R,2R)-1,2-diphenylethylenediamine.
(1S,2S)-(−)-1,2-Diamino-1,2-diphenylethane Packaging, Storage, Delivery, Transportation, etc.
Packing: 100g 1kg drum 25Kg/drum
Storage: Nitrogen protection, air sensitive, keep in dark place, sealed in dry, room temperature
Delivery: delivery within 3- 5 working days
Transportation: According to your needs
FAQ About (1S,2S)-(−)-1,2-Diamino-1,2-diphenylethane
1. What is (1S,2S)-(−)-1,2-Diamino-1,2-diphenylethane?
Answer: It is a chiral molecule with the appearance of white to light yellow crystalline powder and is an important pharmaceutical intermediate.
2. What solvents are suitable for dissolving this compound?
Answer:
- Polar aprotic solvents: Dichloromethane, chloroform.
- Alcohols: DMSO, Methanol, ethanol (partial solubility).
- Avoid water due to limited solubility.
3. What distinguishes (1S,2S)-(−)-1,2-Diamino-1,2-diphenylethane from its enantiomer (1R,2R)-(+)-form?
Answer:
- Stereochemistry: The (1S,2S) configuration is the mirror image of (1R,2R).
- Optical rotation: The (−)-form rotates plane-polarized light to the left, while the (+)-form rotates it to the right.
- Applications: Opposite enantiomers may show different catalytic or biological activities.
