1-Chloropinacolone Basic Information, Physicochemical Properties, etc.
| Basic Information |
| Name |
1-Chloropinacolone |
| Synonyms |
1-chloro-3,3-dimethyl-2-butanone; 1-chloro-3,3-dimethylbutan-2-one; 1-chloropinacolin; 1-chloropinacolone; chloropinacolone; monochloropinakolone; chloropinacoline; 1-chloro-3,3-dimethyl-2-butanone; chloropinacolone |
| CAS Number |
13547-70-1 |
| Molecular Formula |
C6H11ClO |
| Molecular Weight |
134.6 |
| EINECS Number |
236-920-6 |
| Structural Formula |
 |
| Physicochemical Properties |
| Melting Point |
−13 °C(lit.) |
| Boiling Point |
170-173 °C(lit.) |
| Density |
1.025 g/mL at 25 °C(lit.) |
| Refractive Index |
n20/D 1.442(lit.) |
| Flash Point |
153 °F |
| Water Solubility |
Not miscible in water. |
| Form |
Transparent liquid |
| Color |
Colorless to yellow to green |
| Stability |
|
| Acidity Coefficient (pKa) |
|
| Safety and Regulatory Information |
| Merck |
|
| BRN |
|
| NIST Chemical Substance Information |
1-Chloropinacolone | CAS: 13547-70-1 |
| EPA Chemical Substance Information |
1-Chloropinacolone | CAS: 13547-70-1 |
| Other Information |
| Detection Methods |
|
1-Chloropinacolin Application, Use, Usage, Synthesis Method, etc.
- Used as an intermediate for medicines, pesticides, etc.
- As an organic synthesis and pharmaceutical intermediate, it is mainly used in laboratory research and development and chemical production processes.
- It undergoes condensation reactions with many compounds and is widely used in the field of drug preparation and production.
- For example, after the reaction of 1-chloropinacolin with 1,2,4-triazole and phenolic compounds, a series of agricultural chemicals and antibiotic drugs with bactericidal activity can be obtained.
- Used in the synthesis of diniconazole
Synthesis Method
Method 1
2-Methyl-1-butene and 2-methyl-2-butene are added with hydrogen chloride to generate chloro-tert-pentane.
Then it reacts with formaldehyde in an acidic solution to generate pinacol, and chlorine is passed through in the presence of a solvent to obtain 1-chloro-3,3-dimethyl-butan-2-one.
Method 2
1) Add pinacolone-methanol solution into the reactor, turn on the stirring and cooling system, and reduce the temperature of the pinacolone-methanol solution in the reactor to below 0°C.
2) Turn on the circulation pump to circulate the pinacolone-methanol solution from the circulating outlet to the feed inlet of the reactor repeatedly, and set a chlorine adding device and a circulating cooling device on the circulating pipeline. The chlorine adding device passes chlorine into the circulating mother liquor of the reactor, and circulates repeatedly until the reaction is completed to obtain the reaction mother liquor.
3) The reaction mother liquor obtained in step 2 is sent to the desolventizing kettle for heating to desolventize methanol, and the recovered methanol is sent to the raw material pipeline for reuse. After desolventizing, the obtained feed liquid is cooled to obtain 2-butanone, 1-chloro-3,3-dimethyl-.
1-Monochloropinacoline Packaging, Storage, Delivery, Transportation, etc.
Packing: 200kg /drum or Customer specified packaging
Storage: The package is complete and lightly loaded; the warehouse is ventilated, away from open flames, high temperatures, and stored separately from oxidants and acids.
Delivery: delivery within 3- 5 working days
Transportation: According to your needs
FAQ About 1-Chloro-3, 3-Dimethyl-2-Butanone
Where can I buy 1-monochloropinacoline stably? What is the price range?
Answer:
Purchase through professional pharmaceutical intermediate suppliers (such as Sigma, Enamine, or ORIENTRED).
Regarding its price, please feel free to contact us for the latest quotation.
What should I pay attention to when using 1-chloropinacolin?
Answer:
- Wear appropriate protective clothing, gloves and goggles, or masks.
- In case of poor ventilation, wear appropriate respirators.
- In case of an accident or feeling unwell, seek medical attention immediately.
