1,2-Difluorobenzene Basic Information, Physicochemical Properties, etc.
| Basic Information |
| Name |
1,2-Difluorobenzene |
| Synonyms |
Adjacent two fluorine benzene;2-Difluorobenzene;1,2-Difluorobenzene,98+%;o-Difluorobenzene,99%;1,2-Difluorobenzene 98%;1,2-Bifluorobenzene ,98% |
| CAS Number |
367-11-3 |
| Molecular Formula |
C6H4F2 |
| Molecular Weight |
114.09 |
| EINECS Number |
206-680-7 |
| Structural Formula |
 |
| Physicochemical Properties |
| Melting Point |
−34 °C(lit.) |
| Boiling Point |
92 °C(lit.) |
| Density |
1.158 g/mL at 25 °C(lit.) |
| Refractive Index |
n20/D 1.443(lit.) |
| Solubility |
Soluble in chloroform and methanol |
| Water Solubility |
Not miscible or difficult to mix in water. |
| Form |
Liquid |
| Color |
Transparent and colorless |
| Stability |
Stable. Incompatible with strong oxidizing agents. Highly flammable. Note low flash point. |
| Flash Point |
36 °F |
| Safety and Regulatory Information |
| Merck |
|
| BRN |
1905113 |
| NIST Chemical Substance Information |
Benzene, 1,2-difluoro- (cas: 367-11-3) |
| EPA Chemical Substance Information |
Benzene, 1,2-difluoro- (cas: 367-11-3) |
| Other Information |
| Detection Methods |
|
1,2-Difluorobenzene Application, Use, Usage, Synthesis Method, etc.
Application
Pharmaceutical intermediates: 1,2-difluorobenzene is an important raw material for the synthesis of a variety of drugs.
For example, it can be used to synthesize ticagrelor (AZD-6140), which is the first reversibly binding, directly acting, orally administered platelet adenosine diphosphate P2Y12 receptor antagonist. This is a small-molecule anticoagulant used to treat cardiovascular disease.
In addition, 1,2-difluorobenzene can also be used to synthesize other pharmaceutical intermediates through a series of chemical reactions for the preparation of molecules with specific biological activities.
Pesticide intermediates: 1,2-difluorobenzene is an important raw material for the synthesis of pesticides. Through substitution reactions, compounds with insecticidal and fungicidal effects, such as insecticides and thiazolidine fungicides, can be synthesized.
Liquid crystal material intermediates: 1,2-difluorobenzene also has important applications in the synthesis of liquid crystal materials. Through substitution reactions with other compounds, liquid crystal molecules with high-temperature phase change properties and good optical properties can be synthesized.
For example, 1,2-difluorobenzene is an important raw material for synthesizing the new liquid crystal intermediate 2,3-difluoroterephthalaldehyde.
Organic Synthesis: 1,2-difluorobenzene can also be used as an intermediate in organic synthesis, participating in a variety of chemical reactions to produce various organic compounds.
Synthesis Method
Using 2-(trimethylsilyl)phenyl trifluoromethanesulfonate as a raw material, benzene is generated under the action of potassium fluoride and then directly reacted with the introduced fluorine gas to produce the product 1,2-difluorobenzene.
The fluorine gas used in the synthesis is produced by high-temperature cracking of fluorocarbon compounds.
1,2-Difluorobenzene Packaging, Storage, Delivery, Transportation, etc.
Packing: 200kg fiber drum or Customer specified packaging
Storage: Store in a cool, dry place. Store the container tightly closed in a dry, well-ventilated area. Containers that are opened must be carefully resealed and kept upright to prevent leakage.
Delivery: delivery within 3- 5 working days
Transportation: According to your needs
FAQ About 1,2-Difluorobenzene
Where can I buy 1,2-difluorobenzene? What is the price?
You can buy high-quality and cheap o-difluorobenzene from ORIENTRED. And you can contact ORIENTRED at any time to get the latest quotation.
